Case Study

Gold Nanoparticles for Cancer Drug Delivery: A Clinical Application

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By Medic Tech
Updated 1 day ago • 456 views

Overview

Development of gold nanoparticle-based drug carriers for targeted cancer therapy using the Turkevich method.

Medical Therapy / Drug Delivery

Cancer (specifically breast cancer and ovarian cancer)

Experimental Conditions

In vitro: MCF-7 and SKOV-3 cell lines, 37°C, 5% CO₂. In vivo: Female BALB/c mice with xenograft tumors, i.v. injection

Results & Findings

85% reduction in cancer cell viability with minimal toxicity to healthy cells. 3x higher drug accumulation in tumor tissue. 60% tumor reduction after 4 weeks.
Drug Loading Efficiency: 78% Cancer Cell Targeting: 85% specificity Tumor Drug Accumulation: 3x vs free drug Tumor Reduction: 60% after 4 weeks Healthy Cell Viability: >90% maintained

p < 0.001 for tumor reduction vs control (n=15 per group). ANOVA with Tukey post-hoc test.

Successful

Insights

Initial batch-to-batch variability in particle size. Optimization of targeting ligand density required multiple iterations.
Clinical trial planning. Investigation of dual-drug loading. Exploring other cancer types.

Safety Considerations

Biocompatibility confirmed via hemolysis assay (<5%). No acute toxicity observed in animal studies. Long-term biodistribution studies ongoing.

References

  1. Smith et al., Nature Nanotechnology, 2023
  2. Turkevich method: Turkevich et al., 1951
  3. MTT assay protocol: Mosmann, 1983
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Published Jan 2026
Updated 1 day ago

How to Cite This Case Study

APA

Medic Tech. (2026). Gold Nanoparticles for Cancer Drug Delivery: A Clinical Application. Retrieved from https://protoly.net/case-studies/view/gold-nanoparticles-cancer-drug-delivery

MLA

Medic Tech. "Gold Nanoparticles for Cancer Drug Delivery: A Clinical Application." 2026. Web. 12 Jan 2026.

Chicago

Medic Tech. "Gold Nanoparticles for Cancer Drug Delivery: A Clinical Application." Accessed January 12, 2026. https://protoly.net/case-studies/view/gold-nanoparticles-cancer-drug-delivery.